Rob Willemsen Selected Research

Therapeutics

1/2023	Mouse models of fragile X-related disorders.
12/2021	Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation.
1/2021	Allopregnanolone Improves Locomotor Activity and Arousal in the Aged CGG Knock-in Mouse Model of Fragile X-Associated Tremor/Ataxia Syndrome.
1/2017	Combination Therapy in Fragile X Syndrome; Possibilities and Pitfalls Illustrated by Targeting the mGluR5 and GABA Pathway Simultaneously.
1/2015	The quest for targeted therapy in fragile X syndrome.
1/2014	Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome.
5/2004	Prospects of TAT-mediated protein therapy for fragile X syndrome.

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Rob Willemsen Research Topics

Disease

28	Fragile X Syndrome (Martin Bell Syndrome) 11/2018 - 03/2002
27	Fragile X Tremor Ataxia Syndrome 12/2021 - 10/2003
21	Intellectual Disability (Idiocy) 01/2023 - 03/2002
9	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 09/2006
4	Autistic Disorder (Autism) 01/2023 - 08/2011
4	Neoplasms (Cancer) 01/2018 - 07/2004
3	Frontotemporal Dementia (Semantic Dementia) 01/2019 - 09/2006
3	Parkinson Disease (Parkinson's Disease) 01/2019 - 01/2013
3	Parkinsonian Disorders (Parkinsonism) 06/2013 - 02/2011
2	Tremor (Tremors) 11/2018 - 05/2003
2	Prostatic Neoplasms (Prostate Cancer) 01/2013 - 06/2009
2	Disease Progression 08/2011 - 06/2011
1	Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris) 09/2023
1	recessive Spastic paraplegia type 5A 01/2023
1	Hyperopia (Hypermetropia) 01/2021
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2019
1	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 01/2019
1	Huntington Disease (Huntington's Disease) 01/2019
1	Gait Ataxia 11/2018
1	Atrophy 11/2018
1	Cognitive Dysfunction 03/2018
1	Autism Spectrum Disorder 01/2018
1	Glioma (Gliomas) 01/2018
1	Neurodevelopmental Disorders 01/2015
1	Neurofibromatosis 1 (Neurofibromatosis Type I) 01/2015
1	Sarcoma (Soft Tissue Sarcoma) 01/2015
1	Tuberous Sclerosis (Bourneville's Disease) 01/2015
1	Costello Syndrome 01/2015
1	AIDS-Related Complex (ARC) 03/2014
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2014
1	Infertility (Sterility) 01/2014
1	Primary Ovarian Insufficiency 01/2014
1	Hepatocellular Carcinoma (Hepatoma) 08/2013
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 06/2013
1	Multiple System Atrophy 06/2013
1	Alzheimer Disease (Alzheimer's Disease) 06/2013
1	Kufor-Rakeb syndrome 01/2013
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 03/2012
1	Hypokinesia (Bradykinesia) 01/2012
1	Pallidopyramidal syndrome 02/2011
1	Enterocolitis 11/2009

Drug/Important Bio-Agent (IBA)

27	Proteins (Proteins, Gene)FDA Link 09/2023 - 03/2002
12	Messenger RNA (mRNA)IBA 09/2023 - 10/2003
12	Fragile X Mental Retardation ProteinIBA 01/2018 - 12/2002
8	UbiquitinIBA 01/2020 - 05/2003
8	RNA (Ribonucleic Acid)IBA 11/2018 - 09/2005
7	5' Untranslated Regions (5' UTR)IBA 01/2020 - 06/2002
2	Peptides (Polypeptides)IBA 01/2020 - 12/2019
2	enhanced green fluorescent proteinIBA 01/2019 - 07/2009
2	gamma-Aminobutyric Acid (GABA)IBA 01/2017 - 02/2009
2	Sucrose (Saccharose)IBA 03/2014 - 07/2004
2	Biomarkers (Surrogate Marker)IBA 01/2013 - 06/2009
2	RNA-Binding Proteins (RNA-Binding Protein)IBA 05/2012 - 04/2010
2	Levodopa (L Dopa)FDA LinkGeneric 01/2012 - 02/2011
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2023
1	Nuclear Export Signals (Nuclear Export Signal)IBA 02/2021
1	ConnexinsIBA 01/2021
1	Small Cytoplasmic RNAIBA 01/2021
1	Pregnanolone (Allopregnanolone)IBA 01/2021
1	Retinaldehyde (Retinal)IBA 01/2021
1	polyglycineIBA 01/2020
1	Small Interfering RNA (siRNA)IBA 12/2019
1	poly(glycyl-alanyl)IBA 01/2019
1	Antisense RNA (Anti-Sense RNA)IBA 11/2018
1	BC1 RNAIBA 03/2018
1	Arginine (L-Arginine)FDA Link 01/2018
1	Baclofen FDA LinkGeneric 01/2018
1	Histidine (L-Histidine)FDA Link 01/2018
1	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2018
1	trans-sodium crocetinate (crocetin)IBA 01/2015
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2015
1	Sirolimus (Rapamycin)FDA Link 01/2015
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2015
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 05/2014
1	A Kinase Anchor ProteinsIBA 05/2014
1	Proto-Oncogene Proteins c-fos (FRAs)IBA 03/2014
1	Metabotropic Glutamate 5 ReceptorIBA 03/2014
1	Estrogens (Estrogen)FDA Link 01/2014
1	Viral RNAIBA 08/2013
1	Viral ProteinsIBA 08/2013
1	AntibodiesIBA 06/2013
1	SynucleinsIBA 06/2013
1	3' Untranslated Regions (3' UTR)IBA 05/2013
1	MicroRNAs (MicroRNA)IBA 03/2013
1	DNA-Binding Proteins (DNA Binding Protein)IBA 03/2012
1	Dopamine Agonists (Dopamine Agonist)IBA 01/2012
1	Dopamine (Intropin)FDA LinkGeneric 01/2012
1	Apomorphine FDA Link 01/2012
1	ElementsIBA 08/2011
1	Untranslated Regions (Untranslated Region)IBA 08/2011
1	mavoglurantIBA 06/2011
1	Lamin Type A (Lamin A)IBA 01/2010
1	OxazoloneIBA 11/2009
1	Colistin (Coly-Mycin)FDA Link 11/2009
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2009
1	Interleukin-10 (Interleukin 10)IBA 11/2009
1	Peroxidase (Myeloperoxidase)IBA 11/2009
1	Anti-Bacterial Agents (Antibiotics)IBA 11/2009
1	HaptensIBA 11/2009

Therapy/Procedure

7	Therapeutics 01/2023 - 05/2004